Evaluation of peptide-rich root extracts of Calliandria portoriscensis (Jacq.) Benth (Mimosaceae) for in vitro antimicrobial activity and brine shrimp lethality.
Identifieur interne : 000113 ( Main/Exploration ); précédent : 000112; suivant : 000114Evaluation of peptide-rich root extracts of Calliandria portoriscensis (Jacq.) Benth (Mimosaceae) for in vitro antimicrobial activity and brine shrimp lethality.
Auteurs : Omonike O. Ogbole [Nigeria] ; Nkiruka C. Ndabai [Nigeria] ; Toluwanimi E. Akinleye [Nigeria] ; Alfred F. Attah [Nigeria]Source :
- BMC complementary medicine and therapies [ 2662-7671 ] ; 2020.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Anti-infectieux (pharmacologie), Artemia (MeSH), Bactéries à Gram négatif (effets des médicaments et des substances chimiques), Bactéries à Gram positif (effets des médicaments et des substances chimiques), Chromatographie sur couche mince (MeSH), Extraits de plantes (pharmacologie), Extraits de plantes (toxicité), Fabaceae (composition chimique), Masse moléculaire (MeSH), Nigeria (MeSH), Peptides (pharmacologie), Peptides (toxicité), Racines de plante (composition chimique).
- MESH :
- composition chimique : Fabaceae, Racines de plante.
- effets des médicaments et des substances chimiques : Bactéries à Gram négatif, Bactéries à Gram positif.
- pharmacologie : Anti-infectieux, Extraits de plantes, Peptides.
- toxicité : Extraits de plantes, Peptides.
- Animaux, Artemia, Chromatographie sur couche mince, Masse moléculaire, Nigeria.
- Wicri :
- geographic : Nigeria.
English descriptors
- KwdEn :
- Animals (MeSH), Anti-Infective Agents (pharmacology), Artemia (MeSH), Chromatography, Thin Layer (MeSH), Fabaceae (chemistry), Gram-Negative Bacteria (drug effects), Gram-Positive Bacteria (drug effects), Molecular Weight (MeSH), Nigeria (MeSH), Peptides (pharmacology), Peptides (toxicity), Plant Extracts (pharmacology), Plant Extracts (toxicity), Plant Roots (chemistry).
- MESH :
- chemical , pharmacology : Anti-Infective Agents, Peptides, Plant Extracts.
- chemical , toxicity : Peptides, Plant Extracts.
- geographic : Nigeria.
- chemistry : Fabaceae, Plant Roots.
- drug effects : Gram-Negative Bacteria, Gram-Positive Bacteria.
- Animals, Artemia, Chromatography, Thin Layer, Molecular Weight.
Abstract
BACKGROUND
Several Host defence peptides (HDPs) are low molecular weight (< 50 amino acids residues) peptides detected in several ethnomedicinal plants and have particularly gained research interest in recent times. Due to their wide range of bioactivity, occurrence, abundance and ability to induce very little resistance, they hold promising potentials in drug development. This study investigated the presence of bioactive peptides in the roots of Calliandra portoricensis (CPr) (Mimosaceae) and evaluated its antimicrobial activity against gram-negative and gram-positive bacteria.
METHODS
The crude peptide extract was obtained and pre-purified on pre-loaded tube of RP-C
RESULTS
Low molecular weight (LMW) peptides were detected in CPr using TLC and MALDI-TOF MS. Generally, the extracts exhibited good inhibition (70-95%) against the gram-negative and gram-positive bacteria, except MRSA6 typed strain. Enhanced activity was observed in the pre-purified peptide fraction than in the methanol crude, except on MRSA6. The greatest antimicrobial inhibition by pre-purified peptide fraction was against MRSA22 (IC
CONCLUSIONS
This is the first report on detection of bioactive LMW peptides in Mimosaceae family. These peptides appear to be rich in arginine and aromatic amino acids. The peptide extract, in its pre-purified form showed a lower Brine shrimp cytotoxicity and an enhanced antimicrobial activity against the tested gram-negative and gram-positive bacteria.
DOI: 10.1186/s12906-020-2836-6
PubMed: 32020886
PubMed Central: PMC7076830
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Benth (Mimosaceae) for in vitro antimicrobial activity and brine shrimp lethality.</title><author><name sortKey="Ogbole, Omonike O" sort="Ogbole, Omonike O" uniqKey="Ogbole O" first="Omonike O" last="Ogbole">Omonike O. Ogbole</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria. nikeoa@yahoo.com.</nlm:affiliation><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan</wicri:regionArea><orgName type="university">Université d'Ibadan</orgName><placeName><settlement type="city">Ibadan</settlement><region type="region">État d'Oyo</region></placeName></affiliation></author><author><name sortKey="Ndabai, Nkiruka C" sort="Ndabai, Nkiruka C" uniqKey="Ndabai N" first="Nkiruka C" last="Ndabai">Nkiruka C. Ndabai</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria.</nlm:affiliation><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan</wicri:regionArea><orgName type="university">Université d'Ibadan</orgName><placeName><settlement type="city">Ibadan</settlement><region type="region">État d'Oyo</region></placeName></affiliation></author><author><name sortKey="Akinleye, Toluwanimi E" sort="Akinleye, Toluwanimi E" uniqKey="Akinleye T" first="Toluwanimi E" last="Akinleye">Toluwanimi E. Akinleye</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria.</nlm:affiliation><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan</wicri:regionArea><orgName type="university">Université d'Ibadan</orgName><placeName><settlement type="city">Ibadan</settlement><region type="region">État d'Oyo</region></placeName></affiliation></author><author><name sortKey="Attah, Alfred F" sort="Attah, Alfred F" uniqKey="Attah A" first="Alfred F" last="Attah">Alfred F. Attah</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacognosy and Drug Development, Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin, Nigeria. alfattah2000ng@gmail.com.</nlm:affiliation><country xml:lang="fr">Nigeria</country><wicri:regionArea>Department of Pharmacognosy and Drug Development, Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin</wicri:regionArea><wicri:noRegion>Ilorin</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC complementary medicine and therapies</title><idno type="eISSN">2662-7671</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Anti-Infective Agents (pharmacology)</term><term>Artemia (MeSH)</term><term>Chromatography, Thin Layer (MeSH)</term><term>Fabaceae (chemistry)</term><term>Gram-Negative Bacteria (drug effects)</term><term>Gram-Positive Bacteria (drug effects)</term><term>Molecular Weight (MeSH)</term><term>Nigeria (MeSH)</term><term>Peptides (pharmacology)</term><term>Peptides (toxicity)</term><term>Plant Extracts (pharmacology)</term><term>Plant Extracts (toxicity)</term><term>Plant Roots (chemistry)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Anti-infectieux (pharmacologie)</term><term>Artemia (MeSH)</term><term>Bactéries à Gram négatif (effets des médicaments et des substances chimiques)</term><term>Bactéries à Gram positif (effets des médicaments et des substances chimiques)</term><term>Chromatographie sur couche mince (MeSH)</term><term>Extraits de plantes (pharmacologie)</term><term>Extraits de plantes (toxicité)</term><term>Fabaceae (composition chimique)</term><term>Masse moléculaire (MeSH)</term><term>Nigeria (MeSH)</term><term>Peptides (pharmacologie)</term><term>Peptides (toxicité)</term><term>Racines de plante (composition chimique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-Infective Agents</term><term>Peptides</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Peptides</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Nigeria</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Fabaceae</term><term>Plant Roots</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Fabaceae</term><term>Racines de plante</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gram-Negative Bacteria</term><term>Gram-Positive Bacteria</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Bactéries à Gram négatif</term><term>Bactéries à Gram positif</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Anti-infectieux</term><term>Extraits de plantes</term><term>Peptides</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Extraits de plantes</term><term>Peptides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Artemia</term><term>Chromatography, Thin Layer</term><term>Molecular Weight</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Artemia</term><term>Chromatographie sur couche mince</term><term>Masse moléculaire</term><term>Nigeria</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Nigeria</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Several Host defence peptides (HDPs) are low molecular weight (< 50 amino acids residues) peptides detected in several ethnomedicinal plants and have particularly gained research interest in recent times. Due to their wide range of bioactivity, occurrence, abundance and ability to induce very little resistance, they hold promising potentials in drug development. This study investigated the presence of bioactive peptides in the roots of Calliandra portoricensis (CPr) (Mimosaceae) and evaluated its antimicrobial activity against gram-negative and gram-positive bacteria.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>The crude peptide extract was obtained and pre-purified on pre-loaded tube of RP-C</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Low molecular weight (LMW) peptides were detected in CPr using TLC and MALDI-TOF MS. Generally, the extracts exhibited good inhibition (70-95%) against the gram-negative and gram-positive bacteria, except MRSA6 typed strain. Enhanced activity was observed in the pre-purified peptide fraction than in the methanol crude, except on MRSA6. The greatest antimicrobial inhibition by pre-purified peptide fraction was against MRSA22 (IC</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>This is the first report on detection of bioactive LMW peptides in Mimosaceae family. These peptides appear to be rich in arginine and aromatic amino acids. The peptide extract, in its pre-purified form showed a lower Brine shrimp cytotoxicity and an enhanced antimicrobial activity against the tested gram-negative and gram-positive bacteria.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32020886</PMID><DateCompleted><Year>2020</Year><Month>07</Month><Day>29</Day></DateCompleted><DateRevised><Year>2020</Year><Month>07</Month><Day>29</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2662-7671</ISSN><JournalIssue CitedMedium="Internet"><Volume>20</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>Feb</Month><Day>03</Day></PubDate></JournalIssue><Title>BMC complementary medicine and therapies</Title><ISOAbbreviation>BMC Complement Med Ther</ISOAbbreviation></Journal><ArticleTitle>Evaluation of peptide-rich root extracts of Calliandria portoriscensis (Jacq.) Benth (Mimosaceae) for in vitro antimicrobial activity and brine shrimp lethality.</ArticleTitle><Pagination><MedlinePgn>30</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12906-020-2836-6</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Several Host defence peptides (HDPs) are low molecular weight (< 50 amino acids residues) peptides detected in several ethnomedicinal plants and have particularly gained research interest in recent times. Due to their wide range of bioactivity, occurrence, abundance and ability to induce very little resistance, they hold promising potentials in drug development. This study investigated the presence of bioactive peptides in the roots of Calliandra portoricensis (CPr) (Mimosaceae) and evaluated its antimicrobial activity against gram-negative and gram-positive bacteria.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The crude peptide extract was obtained and pre-purified on pre-loaded tube of RP-C<sub>18</sub> solid phase cartridges (strata giga tube C18-E; 5 g, 20 mL, Phenomenex, Germany). Peptide enriched fraction was chemically analysed for arginine-rich/aromatic amino acid-rich peptides using a modified G-250 analytical stain and ninhydrin on thin layer chromatography (TLC) for a preliminary screening. Furthermore, MALDI TOF/TOF peptidomics was used to detect the presence and masses of the peptides. Extracts from CPr were used to test the ability to inhibit microbial growth using p-INT (Para-iodonitrotetrazolium violet) dye, with 0.1% gentamycin as positive control. The concentration that inhibits the growth of microorganisms by 50% (IC<sub>50</sub>) were determined. Toxicity of the two extracts was accessed using freshly hatched nauplii of Artemia salina. Data analysis were evaluated using Microsoft excel and GraphPad Prism5.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Low molecular weight (LMW) peptides were detected in CPr using TLC and MALDI-TOF MS. Generally, the extracts exhibited good inhibition (70-95%) against the gram-negative and gram-positive bacteria, except MRSA6 typed strain. Enhanced activity was observed in the pre-purified peptide fraction than in the methanol crude, except on MRSA6. The greatest antimicrobial inhibition by pre-purified peptide fraction was against MRSA22 (IC<sub>50</sub> = 0.69 ± 0.33 μg/mL). The crude methanol extract (LC<sub>50</sub> = 5.13 μg/mL) was slightly more toxic than the peptide extract (LC<sub>50</sub> = 6.12 μg/mL).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This is the first report on detection of bioactive LMW peptides in Mimosaceae family. These peptides appear to be rich in arginine and aromatic amino acids. The peptide extract, in its pre-purified form showed a lower Brine shrimp cytotoxicity and an enhanced antimicrobial activity against the tested gram-negative and gram-positive bacteria.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ogbole</LastName><ForeName>Omonike O</ForeName><Initials>OO</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-6487-9494</Identifier><AffiliationInfo><Affiliation>Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria. nikeoa@yahoo.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ndabai</LastName><ForeName>Nkiruka C</ForeName><Initials>NC</Initials><AffiliationInfo><Affiliation>Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Akinleye</LastName><ForeName>Toluwanimi E</ForeName><Initials>TE</Initials><AffiliationInfo><Affiliation>Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Attah</LastName><ForeName>Alfred F</ForeName><Initials>AF</Initials><AffiliationInfo><Affiliation>Department of Pharmacognosy and Drug Development, Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin, Nigeria. alfattah2000ng@gmail.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>02</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>BMC Complement Med Ther</MedlineTA><NlmUniqueID>101761232</NlmUniqueID><ISSNLinking>2662-7671</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000890">Anti-Infective Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010455">Peptides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical></ChemicalList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000890" MajorTopicYN="N">Anti-Infective Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001156" MajorTopicYN="N">Artemia</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002855" MajorTopicYN="N">Chromatography, Thin Layer</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007887" MajorTopicYN="N">Fabaceae</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006090" MajorTopicYN="N">Gram-Negative Bacteria</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006094" MajorTopicYN="N">Gram-Positive Bacteria</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008970" MajorTopicYN="N">Molecular Weight</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009549" MajorTopicYN="N" Type="Geographic">Nigeria</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010455" MajorTopicYN="N">Peptides</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018517" MajorTopicYN="N">Plant Roots</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Antimicrobial</Keyword><Keyword MajorTopicYN="N">Brine shrimp lethality assay</Keyword><Keyword MajorTopicYN="N">Calliandra portoricensis</Keyword><Keyword MajorTopicYN="N">Host defence peptides</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>07</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>01</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>2</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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last="Ogbole">Omonike O. Ogbole</name></region><name sortKey="Akinleye, Toluwanimi E" sort="Akinleye, Toluwanimi E" uniqKey="Akinleye T" first="Toluwanimi E" last="Akinleye">Toluwanimi E. Akinleye</name><name sortKey="Attah, Alfred F" sort="Attah, Alfred F" uniqKey="Attah A" first="Alfred F" last="Attah">Alfred F. Attah</name><name sortKey="Ndabai, Nkiruka C" sort="Ndabai, Nkiruka C" uniqKey="Ndabai N" first="Nkiruka C" last="Ndabai">Nkiruka C. Ndabai</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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